In contrast, IFN-α/β enhanced viral replication by inducing the transcription factor HNF3γ and activating STAT3, which together stimulated HBV gene expression and replication. IFN-α/β apparently suppressed HBV replication via transcriptional and post-transcriptional regulations. Interestingly, our results indicated that IFN-α/β could have opposite effects on HBV: they suppressed HBV replication when viral load was high and enhanced HBV replication when viral load was low. By using HBV transgenic mice as a model and by using hydrodynamic injection to introduce HBV DNA into the mouse liver, we studied the effect of IFN-α/β on HBV in vivo. However, the use of IFN-α to treat hepatitis B virus (HBV) patients generated sustained response to only a minority of patients. Interferons α and β (IFN-α/β) are type I interferons produced by the host to control microbial infections. Tian, Yongjun Chen, Wen-ling Ou, Jing-hsiung James Effects of Interferon-α/β on HBV Replication Determined by Viral Load
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